Article reviewed by Prof. Raul Estevez
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a member of the family of leukodystrophies. It is an extremely rare genetic disease. Its frequency is less than 1 per 1,000,000 births, but the disease is more common in certain populations with high consanguinity. It is an orphan disease, which means that there is currently no treatment.